Association between diabetes and vestibular dysfunction: an integrative review
Associação entre diabetes e disfunções do sistema vestibular: revisão integrativa
Roberta Carneiro de Toledo; Cibelle Kayenne Martins Roberto Formiga; Flávio Monteiro Ayres
Abstract
Purpose: to identify, in the literature, the factors associated with the development of vestibular dysfunctions in individuals with type 2 diabetes mellitus (DM2).
Methods: an integrative review of the literature, whose survey was conducted in the databases ISI, SciELO, LILACS and PubMed, using the following descriptors: “type 2 diabetes mellitus”, “vertigo”, “dizziness”, and “vestibular diseases”. Articles published in the last 10 years that answered the research question (“What factors are associated with the development of vestibular disorders in individuals with DM2?”) were included in the study.
Results: the search returned 426 articles, 10 of which met the eligibility criteria. Most of the participants of the selected studies who had vestibular dysfunctions were women over 40 years old and had more than one comorbidity related to DM2, the main one being the systemic arterial hypertension (SAH). According to the literature, the physiology of the inner ear allows small glucose alterations to influence its normal functioning, which makes diabetic individuals more susceptible to developing vestibular dysfunctions.
Conclusion: according to this study, DM2 can trigger or contribute to the manifestation of vestibular dysfunction, whose main associated factors are advanced age, female gender, and various comorbidities, as dyslipidemia, SAH and metabolic syndrome.
Keywords
Resumo
Objetivo: identificar na literatura os fatores que estão associados ao desenvolvimento de disfunções vestibulares em indivíduos com diabetes mellitus tipo 2 (DM2).
Métodos: trata-se de uma revisão integrativa da literatura, cuja busca foi realizada nas bases de dados ISI, Scielo, LILACS e PubMed, sendo utilizados os descritores: “type 2 diabetes mellitus”, “vertigo”, “dizziness” e “vestibular diseases”. Foram incluídos artigos publicados nos últimos dez anos e que respondessem a seguinte questão: quais fatores estão associados ao desenvolvimento de disfunções vestibulares em indivíduos com DM2?
Resultados: a busca resultou em 426 artigos, sendo que 10 atenderam aos critérios de elegibilidade. A maioria dos participantes dos estudos selecionados que apresentaram disfunções vestibulares eram do sexo feminino, idade superior a 40 anos e possuíam mais de uma comorbidade associada a DM2, sendo a principal, a hipertensão arterial sistêmica (HAS). De acordo com a literatura, a fisiologia da orelha interna permite que pequenas alterações de glicose influenciem seu funcionamento normal, o que torna os indivíduos diabéticos mais suscetíveis a desenvolverem disfunções vestibulares.
Conclusão: o presente estudo constatou que a DM2 pode desencadear ou contribuir para a manifestação da disfunção vestibular, tendo como principais fatores associados a idade avançada, o sexo feminino e comorbidades diversas, tais como dislipidemia, HAS e síndrome metabólica.
Palavras-chave
Referências
1. Federação Internacional de Diabetes. Citado em 20 de agosto de 2019. Disponível em: www.idf.org/ metabolic_syndrome, website of the International Diabetes Federation.
2. Sociedade Brasileira de Diabetes. Diretrizes da Sociedade Brasileira de Diabetes (2017-2018). São Paulo: Editora Clannad, 2017.
3. Coqueiro M, Oliveira AE, Figueiredo TAM. Diabetes Mellitus in the printed media: an analysis of the articles in the newspapers of Espírito Santo, Brazil. Saúde Debate. 2019;43(121):530-42. doi: 10.1590/1982-0216/20202214719
4. Ivers RQ, Cumming RG, Mitchell P, Peduto AJ. Diabetes and risk of fracture: the Blue Mountains Eye Study. Diabetes Care. 2001;24(7):1198-203.
5. Bisdorf A, Brevern MV, Lempert T, Newman-Toker DE. Classification of vestibular symptoms: Towards an international classification of vestibular disorders. JVR. 2009;(19):1-13.
6. Borges MGS, Rocha LR, Couto EAB, Mancini PC. Comparison of balance, depression, and cognition in institutionalized and non-institutionalized elderly individuals. Rev. CEFAC. 2015;15(5):1073-9.
7. Coelho AR, Andre APR, Perobellib JLL, Sonobeb LS, Abreu DCC. Immediate effects of an anchor system on the stability limit of individuals with chronic dizziness of peripheral vestibular origin. Braz J Otorhinolaryng. 2017;83(1):3-9.
8. Silva EMT, Lima Filho BF, Mantello EB, Sousa AGP, Diniz Júnior J, Gazzola JM. Diseases and symptoms associated with changes in postural balance in diabetics: an integrating literature review. Rev. CEFAC. 2019;21(6)1-8.
9. Gioacchinni FM, Albera R, Scarpa A, Cassandro C. Hyperglycemia and diabetes mellitus are related to vestibular organs dysfunction: truth or suggestion? A literature review. Acta Diabetol. 2018;55(12):1201-7.
10. Moreira do Nascimento OJ, Castelo C, Pupe B, Boiteux E, Cavalcanti U. Diabetic neuropathy. Rev. dor. 2016;17(Suppl 1):46-51.
11. Mullen R. The state of the evidence: ASHA develops levels of evidence for communication sciences and disorders. 10 de julho de 2019. The ASHA Leader, pp. 8-9, 24-25. Disponível em: http://www.asha.org/publications/leader/2007/070306/f070306b.htm.
12. Chávez-Delgado ME, Vázquez-Granados I, Rosales-Cortés M, Velasco-Rodríguez V. Cochleovestibular dysfunction in patients with diabetes mellitus, hypertension, and dyslipidemia. Acta Otorrinolaringol Esp. 2012;63(2):93-101.
13. Yamanaka T, Fukuda T, Shirota S, Sawai Y, Murai T, Fujita N. The prevalence and characteristics of Metabolic Syndrome in patients with vertigo. Plos One. 2013;8(12):1-5.
14. D’Silva LJ, Staeckerb H, Linb J, Sykesb KJ, Phadnisc MA, McMahond TM et al. Retrospective data suggests that the higher prevalence of benign paroxysmal positional vertigo in individuals with type 2 diabetes is mediated by hypertension. JVR. 2015;25(5):233-9.
15. Ward BK, Wenzel A, Kalyani RR, Agrawal Y, Feng AL, Polydefkis M et al. Characterization of vestibulopathy in individuals with type 2 diabetes mellitus. Otolaryngol Head Neck Surg. 2015;153(1):112-8.
16. Albernaz PLM. Hearing loss, dizziness, and carbohydrate metabolism. Int Arch Otorhinolaryngol. 2016;20(3):261-70.
17. D’Silva LJ, Staecker H, Lin J, Maddux C, Ferraro J, Dai H et al. Otolith dysfunction in persons with both diabetes and benign paroxysmal positional vertigo. Otology&Neurotology. 2017;38(3):379-85.
18. Jaugueri-Renaud K, Aranda-Moreno C, Herrera-Rangel A. Utricular hypofunction in patients with type 2 diabetes mellitus. Acta Otorhinolaryngol Ital. 2017;37(5):430-5.
19. D’Silva LJ, Whitney SL, Santos M, Dai H, Kluding PM. The impact of diabetes on mobility, balance, and recovery after repositioning maneuvers in individuals with benign paroxysmal positional vertigo. J Diabet Complicat. 2017;31(6):976-82.
20. Bepari K, Panditray S, Palai S, Jyotishi B. A comparative study of metabolic disorders in vertigo. J Evolution Med DentSci. 2018;7(2):188-93.
21. Naik CS, Tiloo R. Vestibular dysfunction and glycemic control in Diabetes Mellitus: Is there a correlation? Indian J of Otology. 2019;24(3):199-203.
22. Marchiori LLM, Melo JJ, Possette FLF, Correa AL. Comparison of frequency of vertigo in elderly with and without arterial hypertension. Arq Int Otorrinolaringol. 2010;14(4):456-60.
23. Ribeiro WA, Mariano ES, Cirino HP, Teixeira JM, Martins LM, Andrade M. Health education for patients with diabetes mellitus and hypertension in family health strategy. Rev Pró-Univer SUS. 2017;8(2):110-4.
24. Lee H. Recent advances in acute hearing loss due to posterior circulation ischemic stroke. J NeurolSci. 2014;38(8):23-9.
25. Malucelli DA, Malucelli FJ, Fonseca VR, Zeigeboim B, Ribas A, Trotta FD et al. Hearingloss prevalence in patients with diabetes mellitus type
26. Kammerlind ASC, Bravell ME, Fransson EI. Prevalence of and factors related to mild and substantial dizziness in communitydwelling older adults: a cross-sectional study. BMC Geriatrics. 2016;16(1):151-9. doi: 10.1590/1982-0216/20202214719 Toledo RC, Formiga CKMR, Ayres FM
27. Hateren KJV, Kleefstra N, Blanker MH, Ubink-Veltmaat LJ, Groenier KH, Houweling ST et al. Orthostatic hypotension, diabetes, and falling in older patients: a cross-sectional study. Br J Gen Pract. 2012;62(603):696-702.
28. Kamgar M, Nobakhthaghighi N, Shamshirsaz AA, Estacio RO, McFann KK, Schrier RW. Impaired fibrinolytic activity in type II diabetes: correlation with urinary albumin excretion and progression of renal disease. Kidney Int. 2006;69(10):1899-903.
29. Deli G, Bosnyak E, Pusch G, Komoly S, Feher G. Diabeticneuropathies: diagnosis and management. Neuroendocrinology. 2013;98(4):267-80.
30. Cohen HS, Kimball KT, Stewart MG. Benign paroxysmal positional vertigo and comorbid conditions. ORL J Otorhinolaryngol Relat Spec. 2004;66(1):11-5.
31. Von Brevern M, Bertholon P, Brandt T, Fife T, Imai T, Nuti D. Benign paroxysmal positional vertigo: Diagnostic Criteria Consensus Document of the Committee for the Classification of Vestibular Disorders of the Bárány Society. Acta Otorrinolaringol Esp. 2017;68(6):349-60.
32. Ganança FF. Elderly falls associated with benign paroxysmal positional vertigo. Braz J Otorhinolaryngol. 2010;76(1):113-20.
Submetido em:
23/05/2019
Aceito em:
12/03/2020
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